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| Title:
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The effect of noise on beta-cell burst period |
| Type:
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Journal articleJournal article |
| Participant(s):
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Technical University of Denmark
Technical University of Denmark
Email:
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| Abstract:
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Bursting electrical behavior is commonly observed in a variety of nerve and endocrine cells,
among these in electrically coupled beta-cells located in intact pancreatic islets. However, individual beta-cells usually
display either spiking or very fast bursting behavior, and the difference between isolated and coupled cells has
been suggested to be due to stochastic fluctuations of the plasma membrane ions channels, which are supposed
to have a stronger effect on single cells than on cells situated in clusters (the channel sharing hypothesis). This
effect of noise has previously been studied based on numerical simulations. We show here how the application of
two recent methods allows an analytic treatment of the stochastic effects on the location of the saddle-node and
homoclinic bifurcations, which determine the burst period. Thus, the stochastic system can be analyzed similarly
to the deterministic system, but with a quantitative description of the effect of noise. This approach supports
previous investigations of the channel sharing hypothesis. |
| Published:
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in journal: S I A M Journal on Applied Mathematics (ISSN: 0036-1399) (DOI: http://dx.doi.org/10.1137/060655663), vol: 67, issue: 2, pages: 530-542, 2006 |
| DOI:
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