DanskDTU.dkIndexContactPhone bookDTU AlumniPortalen
English > Staff > Scientific staff
DTU Mathematics staff
Scientific staff
Administrative staff
PhD students
Postdoc
Emeriti
External staff
Guests
DTU staff
Title: Modelling of the Blood Coagulation Cascade in an In Vitro Flow System.
Type: Journal articleJournal article
Participant(s):
Author:  Andersen, Nina Marianne (Cwisno: 17688)
Technical University of Denmark
Email:

Author:  Sørensen, Mads Peter (Cwisno: 2425)
Technical University of Denmark
Email:

Forfatter:  Efendiev, Messoud A.
Helmholtz Zentrum München, Germany, Institute of Biomathematics and Biometry

Forfatter:  Olsen, Ole Hvilsted
Novo Nordisk A/S, Denmark, Haemostasis Biochemistry

Forfatter:  Ingwersen, Steen H.
Novo Nordisk A/S, Denmark, Biomodelling
Abstract: We derive a mathematical model of a part of the blood coagulation cascade set up in a perfusion experiment. Our purpose is to simulate the influence of blood flow and diffusion on the blood coagulation pathway. The resulting model consists of a system of partial differential equations taking into account the spatial distribution of the biochemical species. An important issue is inclusion of a dynamic boundary condition describing adhesion of activated platelets on a collagen coated top lid in the perfusion chamber. The validity of the model is established through criteria on the reaction diffusion and flow equations, which guarantee non negative concentrations at all times. The criteria is applied to the model of the blood coagulation cascade.
Published: in journal: International Journal of Biomathematics and Biostatistics (ISSN: 0973-7340), vol: 1, issue: 1, pages: 1-7, 2010
File(s):
See the publication in DTU Orbit See the publication in DTU Orbit

Top
Matematiktorvet303 BDK-2800 Kgs. LyngbyTel +45 4525 3031VAT 63393010EAN 5798000428515
Cookies